丝氨酸/苏氨酸激酶36融合同源蛋白抗体

产品货号：

BN41164R
中文名称：

丝氨酸/苏氨酸激酶36融合同源蛋白抗体
英文名称：

Rabbit anti-STK36 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41164R-100ul

100ul

¥2360.00

交叉反应：Human,Mouse(predicted:Rat,Dog,Pig,Horse,Sheep) 推荐应用：WB,IHC-P,Flow-Cyt,ELISA
BN41164R-200ul

200ul

¥3490.00

交叉反应：Human,Mouse(predicted:Rat,Dog,Pig,Horse,Sheep) 推荐应用：WB,IHC-P,Flow-Cyt,ELISA

产品描述

英文名称	STK36
中文名称	丝氨酸/苏氨酸激酶36融合同源蛋白抗体
别名	FU antibody Fused homolog; KIAA1278; Serine/threonine kinase 36, fused homolog; STK36_HUMAN.
研究领域	肿瘤细胞生物免疫学激酶和磷酸酶
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, (predicted: Rat, Dog, Pig, Horse, Sheep, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=1ug/Test （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	144kDa
细胞定位	细胞核细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human STK36:21-120/1315
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	Serine/threonine protein kinase required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Function: Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia. Subunit: Interacts with SPAG16 and KIF27 (By similarity). Subcellular Location: Cytoplasm. Nucleus. Note=Low levels also present in the nucleus. Tissue Specificity: Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells. Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain. SWISS: Q9NRP7 Gene ID: 27148 Database links: Entrez Gene: 27148 Human Entrez Gene: 269209 Mouse Entrez Gene: 301516 Rat Omim: 607652 Human SwissProt: Q9NRP7 Human SwissProt: Q69ZM6 Mouse Unigene: 471404 Human Unigene: 712986 Human Unigene: 310974 Mouse Unigene: 198846 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.