磷酸化干扰素α受体抗体

产品货号：

BN41099R
中文名称：

磷酸化干扰素α受体抗体
英文名称：

Rabbit anti-phospho-IFNAR1 (Ser535+Ser539) Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41099R-100ul

100ul

¥2470.00

交叉反应：Rat,Human(predicted:GuineaPig,Sheep,Horse,Cow,Pig,Dog,Mouse) 推荐应用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

产品描述

英文名称	phospho-IFNAR1 (Ser535+Ser539)
中文名称	磷酸化干扰素α受体抗体
别名	IFNAR1 (phospho S535 + S539); p-IFNAR1 (phospho S535 + S539); IFN alpha REC; IFN alpha receptor; IFN alpha/beta Receptor alpha; IFN beta receptor; IFNAR; IFNAR1; IFRC; Interferon alpha/beta receptor alpha chain; INAR1_HUMAN.
产品类型	磷酸化抗体
研究领域	肿瘤细胞生物免疫学信号转导细胞凋亡转录调节因子
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Rat, (predicted: Mouse, Dog, Pig, Cow, Horse, Sheep, Guinea Pig, )
产品应用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2ug/tets IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	61kDa
细胞定位	细胞膜
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated Synthesised phosphopeptide derived from human IFNAR1 around the phosphorylation site of Ser535+Ser539:QD(p-S)GNY(p-S)NE
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	IFNAR1 is a member of the cytokine receptor superfamily which also includes receptors for interleukins, IFN gamma, ciliary neurotrophic factor, somatotrophin, erythropoietin, nerve growth factor, tumor necrosis factor, leukemia inhibitory factor, and oncostatin M. Some members of the family have an alpha chain with either low or high ligand binding affinity and at least one beta chain involved in signal transduction with either relatively low or no ligand binding affinity. Type I interferons, alpha and beta, induce a variety of effects on target cells including antiviral, antiproliferative, and immunomodulatory activities. The alpha and beta interferons compete to bind to a common cell surface receptor, while IFN gamma binds to a distinct receptor. IFNAR1 is very responsive to type I interferons and bind to IFN beta and IFN alpha subtypes. It is also functionally involved in signal transduction because of its association with the cytoplasmic tyrosine kinase JAK1. The type I interferons, alpha and beta, are produced by leukocytes (alpha subunits), fibroblasts (beta subtypes), lymphocytes (omega subtypes), and ruminant embryos (tau subtypes). Interferon receptors are generally found on most human cell types whatever their origin, even on cells poorly responsive to interferon. IFNAR1 is expressed on the cell surface in a variety of human cell lines. Function: Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Subunit: Belongs to the type II cytokine receptor family. Contains 3 fibronectin type-III domains. Subcellular Location: Membrane. Tissue Specificity: IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. Post-translational modifications: Phosphorylated on tyrosine residues by TYK2 tyrosine kinase. Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2. SWISS: P17181 Gene ID: 3454 Database links: Entrez Gene: 3454 Human Omim: 107450 Human SwissProt: P17181 Human Unigene: 529400 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.