肝血管生成素相关蛋白4抗体

产品货号：

BN41034R
中文名称：

肝血管生成素相关蛋白4抗体
英文名称：

Rabbit anti-Angiopoietin-like 4 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN41034R-100ul

100ul

¥2360.00

交叉反应：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Rabbit) 推荐应用：WB,ELISA
BN41034R-200ul

200ul

¥3490.00

交叉反应：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Rabbit) 推荐应用：WB,ELISA

产品描述

英文名称	Angiopoietin-like 4
中文名称	肝血管生成素相关蛋白4抗体
别名	Angiopoietin like 4; Angiopoietin related protein 4; Angiopoietin-like protein 4; Angiopoietin-related protein 4; ANGL4_MOUSE; ANGPT L2; ANGPT L4; ANGPTL2; ANGPTL4; ARP4; Fasting induced adipose factor; FIAF; Hepatic angiopoietin related protein; Hepatic fibrinogen/angiopoietin related protein; Hepatic fibrinogen/angiopoietin-related protein; HFARP; NL2; Peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin related protein; PGAR; pp1158; PPARG angiopoietin related protein; PSEC0166; Weakly similar to angiopoietin 1 [H.sapiens]; ANGL4_HUMAN.
研究领域	肿瘤细胞生物免疫学转录调节因子
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Rabbit, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	42kDa
细胞定位	细胞外基质分泌型蛋白
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from mouse ARP4:331-410/410
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Sep 2013] Function: Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorgenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation. Subunit: Homooligomer. The homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like domain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix. Subcellular Location: Secreted. Secreted, extracellular space, extracellular matrix. Tissue Specificity: Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney. Post-translational modifications: N-glycosylated. Similarity: Contains 1 fibrinogen C-terminal domain. SWISS: Q9Z1P8 Gene ID: 57875 Database links: Entrez Gene: 51129 Human Omim: 605910 Human SwissProt: Q9BY76 Human Unigene: 9613 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.