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首页>>免疫学>>一抗>>囊泡对接蛋白p115抗体
囊泡对接蛋白p115抗体
  • 产品货号:
    BN41006R
  • 中文名称:
    囊泡对接蛋白p115抗体
  • 英文名称:
    Rabbit anti-Vesicle docking protein p115 Polyclonal antibody
  • 品牌:
    Biorigin
  • 货号

    产品规格

    售价

    备注

  • BN41006R-100ul

    100ul

    ¥2360.00

    交叉反应:Human,Mouse(predicted:Rat,Chicken,Pig,Cow,Horse,Sheep) 推荐应用:WB,IHC-P,IHC-F,IF,ELISA

  • BN41006R-200ul

    200ul

    ¥3490.00

    交叉反应:Human,Mouse(predicted:Rat,Chicken,Pig,Cow,Horse,Sheep) 推荐应用:WB,IHC-P,IHC-F,IF,ELISA

产品描述

英文名称Vesicle docking protein p115
中文名称囊泡对接蛋白p115抗体
别    名P115-RhoGEF General vesicular transport factor; General vesicular transport factor p115; P115; TAP; Transcytosis associated protein; VDP; Vesicle docking protein; USO1_HUMAN.  
研究领域免疫学  信号转导  结合蛋白  G蛋白偶联受体  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse,  (predicted: Rat, Chicken, Pig, Cow, Horse, Sheep, )
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量108kDa
细胞定位细胞浆 细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Vesicle docking protein p115:501-600/962 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍p115 (Vesicle docking protein p115) is a peripheral membrane protein that is located on the Golgi complex. p115 exists as a homodimer with two globular heads, an extended coiled-coil tail, followed by an acidic domain at the extreme C terminus. p115 is homologous to a yeast protein, Uso1p, which is required for ER to Golgi transport. p115 likely plays an important role in vesicle transportation from the ER to the cis-Golgi comparments.

Function:
General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.

Subunit:
Homodimer. Dimerizes by parallel association of the tails, resulting in an elongated structure with two globular head domains side by side, and a long rod-like tail structure (Probable). Interacts with MIF.

Subcellular Location:
Cytoplasm; cytosol. Golgi apparatus membrane. Recycles between the cytosol and the Golgi apparatus during interphase. During interphase, the phosphorylated form is found exclusively in cytosol; the unphosphorylated form is associated with Golgi apparatus membranes.

Post-translational modifications:
Phosphorylated in a cell cycle-specific manner; phosphorylated in interphase but not in mitotic cells. Dephosphorylated protein associates with the Golgi membrane; phosphorylation promotes dissociation.

Similarity:
Belongs to the VDP/USO1/EDE1 family.
Contains 10 ARM repeats.

SWISS:
O60763

Gene ID:
8615

Database links:

Entrez Gene: 317724 Cow

Entrez Gene: 8615 Human

Entrez Gene: 56041 Mouse

Entrez Gene: 56042 Rat

Omim: 603344 Human

SwissProt: P41541 Cow

SwissProt: O60763 Human

SwissProt: Q9Z1Z0 Mouse

SwissProt: P41542 Rat

Unigene: 292689 Human

Unigene: 15868 Mouse

Unigene: 4746 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.