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首页>>免疫学>>一抗>>线粒体异柠檬酸脱氢酶抗体
线粒体异柠檬酸脱氢酶抗体
  • 产品货号：
    BN40983R
  • 中文名称：
    线粒体异柠檬酸脱氢酶抗体
  • 英文名称：
    Rabbit anti-IDH2 Polyclonal antibody
  • 品牌：
    Biorigin

  • 货号

    产品规格

    售价

    备注

  • BN40983R-100ul

    100ul

    ¥2360.00

    交叉反应：Human,Rat(predicted:Mouse,Dog,Horse) 推荐应用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN40983R-200ul

    200ul

    ¥3490.00

    交叉反应：Human,Rat(predicted:Mouse,Dog,Horse) 推荐应用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

产品描述

英文名称IDH2
中文名称线粒体异柠檬酸脱氢酶抗体
别    名mitochondrial; ICD-M; IDH; IDH2; IDHP_HUMAN; IDP; Isocitrate dehydrogenase [NADP]; Isocitrate dehydrogenase [NADP], mitochondrial; mNADP-IDH; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase


研究领域肿瘤  细胞生物  免疫学  染色质和核信号  转录调节因子  激酶和磷酸酶  新陈代谢  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Rat,  (predicted: Mouse, Dog, Horse, )
产品应用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2ug/test IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量51kDa
细胞定位细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human IDH2:251-350/452 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍IDH2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial), also designated NADP+-specific ICDH; isocitrate dehydrogenase, mitochondrial; and oxalosuccinate decarboxylase, is a 452 amino acid enzyme encoded by the human gene IDH2. IDH2 belongs to the isocitrate and isopropylmalate dehydrogenases family and contains two nucleotide binding regions. IDH2 is involved in the reduction of NADP+ to NADPH and maintains the supply of glutathione (GSH) in mitochondria. It is believed to play a role in intermediary metabolism and energy production. IDH2 also tightly associates with the pyruvate dehydrogenase complex. IDH2 is found in the mitochondrion as a homodimer and can bind one magnesium or manganese ion per subunit.

Function:
Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.

Subunit:
Homodimer.

Subcellular Location:
Cytoplasm. Peroxisome.

DISEASE:
Defects in IDH1 are involved in the development of glioma (GLM) [MIM:137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Mutations affecting Arg-132 are tissue-specific, and suggest that this residue plays a unique role in the development of high-grade gliomas. Mutations of Arg-132 to Cys, His, Leu or Ser abolish magnesium binding and abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate. Elevated levels of R(-)-2-hydroxyglutarate are correlated with an elevated risk of malignant brain tumors.

Similarity:
Belongs to the isocitrate and isopropylmalate dehydrogenases family.

SWISS:
P48735

Gene ID:
3418

Database links:

Entrez Gene: 3418 Human

Entrez Gene: 269951 Mouse

Entrez Gene: 361596 Rat

Omim: 147650 Human

SwissProt: P48735 Human

SwissProt: P54071 Mouse

SwissProt: P56574 Rat

Unigene: 596461 Human

Unigene: 246432 Mouse

Unigene: 290925 Mouse

Unigene: 3490 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

IDH2又称异柠檬酸脱氢酶，他有有两种类型的酶：以NAD为辅酶的酶（EC1．1．1．41）和NADP的酶（EC1．1．1．42），两者催化同一反应。在胞浆中以NADP为辅酶，在线粒体内膜以NAD为辅酶。 　　 IDH2在三羧酸循环中正常起作用的是NAD为辅酶的酶，他是提供为ADP激活的变构酶。