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BN40975R-100ul
100ul
¥2360.00
交叉反应：Human,Mouse,Rat(predicted:Cow,Rabbit) 推荐应用：IHC-P,IHC-F,IF,ELISA
BN40975R-200ul
200ul
¥3490.00
交叉反应：Human,Mouse,Rat(predicted:Cow,Rabbit) 推荐应用：IHC-P,IHC-F,IF,ELISA
产品描述
| 英文名称 | ATG4A |
| 中文名称 | 自噬相关蛋白4A抗体 |
| 别 名 | AI627006 ; APG4 autophagy 4 homolog A ; Apg4a ; ATG4 autophagy related 4 homolog A (S. cerevisiae) ; ATG4 autophagy related 4 homolog A ; ATG4A ; ATG4A_HUMAN ; Atg4al ; AUT like 2 cysteine endopeptidase ; AUT-like 2 cysteine endopeptidase ; Autl2 ; Autophagin 2 ; Autophagin-2 ; Autophagy related 4A cysteine peptidase ; Autophagy related cysteine endopeptidase 2 ; Autophagy related protein 4 homolog A ; Autophagy-related cysteine endopeptidase 2 ; Autophagy-related protein 4 homolog A ; AV169859 ; Cysteine protease ATG4A ; hAPG4A ; MGC107179 . |
| 研究领域 | 肿瘤 免疫学 细胞凋亡 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, (predicted: Cow, Rabbit, ) |
| 产品应用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 45kDa |
| 细胞定位 | 细胞浆 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ATG4A:51-150/398 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | ATG4A is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Function: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Subcellular Location: Cytoplasm (Probable). Tissue Specificity: Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver. Similarity: Belongs to the peptidase C54 family. SWISS: Q8WYN0 Gene ID: 115201 Database links: Entrez Gene: 115201 Human Entrez Gene: 666468 Mouse Omim: 300663 Human SwissProt: Q8WYN0 Human SwissProt: Q8C9S8 Mouse Unigene: 8763 Human Unigene: 102230 Mouse Unigene: 393320 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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