磷酸化亲环蛋白（亲环素）PPIG抗体

产品货号：

BN40925R
中文名称：

磷酸化亲环蛋白（亲环素）PPIG抗体
英文名称：

Rabbit anti-Phospho-PPIG (Ser376) Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40925R-100ul

100ul

¥2470.00

交叉反应：Human,Mouse(predicted:Rat,Chicken,Dog,Pig,Cow,Horse,Sheep) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

产品描述

英文名称	Phospho-PPIG (Ser376)
中文名称	磷酸化亲环蛋白（亲环素）PPIG抗体
别名	CARS cyclophilin; CARS Cyp; CASP 10; CASP10; Clk associating RS cyclophilin; Cyclophilin G; CyclophilinG; CYP; MGC133241; Peptidyl prolyl cis trans isomerase G; Peptidyl prolyl isomerase G; Peptidylprolyl isomerase G (cyclophilin G); Peptidylprolyl isomerase G; PPIase G; Rotamase G; RotamaseG; PPIG_HUMAN.
产品类型	磷酸化抗体
研究领域	细胞生物免疫学染色质和核信号
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	89kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated Synthesised phosphopeptide derived from human PPIG around the phosphorylation site of Ser376:VS(p-S)GE
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	PPIG belongs to the the peptidyl-prolyl cis/trans isomerase protein family (PPIases). PPIases accelerate the folding of proteins. PPIG catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and is implicated in the folding, transport, and assembly of proteins. It is distributed in nuclear speckles, a nuclear compartment rich in splicing factors, and colocalizes with the splicing factors SC35 and pinin, suggesting a role in the regulation of pre-mRNA splicing. Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. Subunit: Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II. Subcellular Location: Nucleus matrix. Nucleus speckle. Note=Colocalizes with RNA splicing factors at nuclear speckles. Tissue Specificity: Ubiquitous. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 1 PPIase cyclophilin-type domain. SWISS: Q13427 Gene ID: 9360 Database links: Entrez Gene: 9360 Human Entrez Gene: 228005 Mouse Entrez Gene: 83624 Rat Omim: 606093 Human SwissProt: Q13427 Human SwissProt: A2AR02 Mouse SwissProt: O55035 Rat Unigene: 727580 Human Unigene: 11815 Mouse Unigene: 474951 Mouse Unigene: 10898 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 肽基脯氨酰基顺反异构酶，广泛存在于各种组织和器官。根据对免疫抑制剂的敏感性，分属三个独立的家族：亲环蛋白PPIG、FK506结合蛋白和细蛋白。能够加速自身折叠和体内新生肽链折叠及变性蛋白质的体外折叠，主要分布于内质网。