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首页>>免疫学>>一抗>>磷酸化组蛋白去乙酰化酶6抗体
磷酸化组蛋白去乙酰化酶6抗体
  • 产品货号：
    BN40881R
  • 中文名称：
    磷酸化组蛋白去乙酰化酶6抗体
  • 英文名称：
    Rabbit anti-phospho-HDAC6 (Ser22) Polyclonal antibody
  • 品牌：
    Biorigin

  • 货号

    产品规格

    售价

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  • BN40881R-100ul

    100ul

    ¥2470.00

    交叉反应：Human 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

产品描述

英文名称phospho-HDAC6 (Ser22)
中文名称磷酸化组蛋白去乙酰化酶6抗体
别    名HDAC6 (phospho S22); p-HDAC6 (phospho S22); HDAC6 (phospho Ser22); p-HDAC6 (Ser22); HD 6; HD6; HDAC 6; Histone deacetylase 6; HD6; Histone deacetylase 6; JM 21; JM21; KIAA0901; FLJ16239; HDAC6_HUMAN.  
产品类型磷酸化抗体 
研究领域肿瘤  免疫学  发育生物学  信号转导  细胞凋亡  转录调节因子  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, 
产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量134kDa
细胞定位细胞核 细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human HDAC6 around the phosphorylation site of Ser22:PQ(p-S)PP 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍HDAC6 is a member of the class II mammalian histone deacetylases. Human HDAC6 is composed of 1215 amino acid residues. It possesses two separate putative catalytic domains. Both catalytic domains are fully functional HDACs and contribute independently to the overall activity of HDAC6 protein. A very potent NES is present at the amino-terminus of HDAC6, which was found to play an important role in regulating the shuttling of HDAC6 protein between cytoplasm and nucleus. The shuttling process may be a critical regulatory mechanism of HDAC6 function. The expression of HDAC6 is tightly linked to the state of cell differentiation. HDAC6 may participate in coordinating expression of a group of genes involved in the remodelling of chromatin during cell differentiation.

Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.

Subunit:
Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with CYLD. Interacts with ZMYND15 (By similarity). Interacts with DDIT3/CHOP.

Subcellular Location:
Nucleus. Cytoplasm. Note=It is mainly cytoplasmic, where it is associated with microtubules.

Post-translational modifications:
Phosphorylated by AURKA.
Ubiquitinated. Its polyubiquitination however does not lead to its degradation.
Sumoylated in vitro.

Similarity:
Belongs to the histone deacetylase family. HD type 2 subfamily.
Contains 1 UBP-type zinc finger.

SWISS:
Q9UBN7

Gene ID:
10013

Database links:

Entrez Gene: 10013 Human

Entrez Gene: 15185 Mouse

Entrez Gene: 84581 Rat

Omim: 300272 Human

SwissProt: Q9UBN7 Human

SwissProt: Q9Z2V5 Mouse

Unigene: 6764 Human

Unigene: 29854 Mouse

Unigene: 13453 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

    HDAC6是一种比较独特的组蛋白去乙酰化酶，含有两个功能上相互独立的HDAC催化结构域。HDAC6可以去乙酰化组蛋白并抑制相关基因转录。
    HDAC6可以和微管(microtuble)结合，可以去乙酰化tubulin，Hsp90和cortactin等。目前发现大量的蛋白可以被乙酰化修饰，因此HDAC等乙酰化修饰酶被认为在基因转录调控、信号转导、生长发育、分化凋亡、代谢性疾病和肿瘤等多种生理病理过程中发挥重要作用。HDAC的抑制剂目前被认为是很有前景的肿瘤治疗药物。
    内源性HDAC6主要定位于细胞浆，与微管相结合并且是一个微管蛋白去乙酰化酶。HDAC6含有一个锌指结构域，该结构域可能和泛素化降解的调节有关。HDAC6可以和DHAC11相互作用。