组蛋白去乙酰化酶8抗体

产品货号：

BN40836R
中文名称：

组蛋白去乙酰化酶8抗体
英文名称：

Rabbit anti-HDAC8 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40836R-100ul

100ul

¥2360.00

交叉反应：Mouse(predicted:Human,Rat,Chicken,Pig,Cow,Horse,Rabbit) 推荐应用：IHC-P,IHC-F,IF,ELISA
BN40836R-200ul

200ul

¥3490.00

交叉反应：Mouse(predicted:Human,Rat,Chicken,Pig,Cow,Horse,Rabbit) 推荐应用：IHC-P,IHC-F,IF,ELISA

产品描述

英文名称	HDAC8
中文名称	组蛋白去乙酰化酶8抗体
别名	HD 8; HD8; HDAC 8; HDACL 1; HDACL1; Histone deacetylase 8; Histone deacetylase like 1; RPD 3; RPD3; CDA07; Hdac8; HDAC8_HUMAN.
研究领域	肿瘤发育生物学信号转导细胞凋亡转录调节因子表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Mouse, (predicted: Human, Rat, Chicken, Pig, Cow, Horse, Rabbit, )
产品应用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	42kDa
细胞定位	细胞核细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human HDAC8:151-250/377
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]. Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility. Subunit: Interacts with PEPB2-MYH11, a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11 produced by the inversion Inv(16)(p13q22), a translocation associated with acute myeloid leukemia of M4EO subtype. The PEPB2-MYH1 fusion protein also interacts with RUNX1, a well known transcriptional regulator, suggesting that the interaction with HDAC8 may participate in the conversion of RUNX1 into a constitutive transcriptional repressor. Interacts with CBFA2T3. Interacts with phosphorylated SMG5/EST1B; this interaction protects SMG5 from ubiquitin-mediated degradation. Associates with alpha-SMA (smooth muscle alpha-actin). Subcellular Location: Nucleus. Cytoplasm. Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation. Tissue Specificity: Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney. Post-translational modifications: Phosphorylated by PKA on serine 39. Phosphorylation reduces deacetylase activity observed preferentially on histones H3 and H4. Similarity: Belongs to the histone deacetylase family. HD type 1 subfamily. SWISS: Q9BY41 Gene ID: 55869 Database links: Entrez Gene: 55869 Human Entrez Gene: 70315 Mouse Entrez Gene: 363481 Rat Omim: 300269 Human SwissProt: Q9BY41 Human SwissProt: Q8VH37 Mouse SwissProt: B1WC68 Rat Unigene: 310536 Human Unigene: 328128 Mouse Unigene: 208476 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.