组蛋白去乙酰化酶6抗体

产品货号：

BN40834R
中文名称：

组蛋白去乙酰化酶6抗体
英文名称：

Rabbit anti-HDAC6 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40834R-100ul

100ul

¥2360.00

交叉反应：Human,Rat(predicted:Mouse,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN40834R-200ul

200ul

¥3490.00

交叉反应：Human,Rat(predicted:Mouse,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

产品描述

英文名称	HDAC6
中文名称	组蛋白去乙酰化酶6抗体
别名	HD 6; HD6; HDAC 6; Histone deacetylase 6; HD6; Histone deacetylase 6; JM 21; JM21; KIAA0901; FLJ16239; HDAC6_HUMAN.
研究领域	肿瘤发育生物学信号转导细胞凋亡转录调节因子表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Rat, (predicted: Mouse, Cow, Horse, Rabbit, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	134kDa
细胞定位	细胞核细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human HDAC6:301-400/1215
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]. Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy. Subunit: Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with CYLD. Interacts with ZMYND15 (By similarity). Interacts with DDIT3/CHOP. Subcellular Location: Nucleus. Cytoplasm. Note=It is mainly cytoplasmic, where it is associated with microtubules. Post-translational modifications: Phosphorylated by AURKA. Ubiquitinated. Its polyubiquitination however does not lead to its degradation. Sumoylated in vitro. Similarity: Belongs to the histone deacetylase family. HD type 2 subfamily. Contains 1 UBP-type zinc finger. SWISS: Q9UBN7 Gene ID: 10013 Database links: Entrez Gene: 10013 Human Entrez Gene: 15185 Mouse Entrez Gene: 84581 Rat Omim: 300272 Human SwissProt: Q9UBN7 Human SwissProt: Q9Z2V5 Mouse Unigene: 6764 Human Unigene: 29854 Mouse Unigene: 13453 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 组蛋白去乙酰化酶(HDACs)是一组在细胞染色质水平、通过诱导组蛋白去乙酰化来调控包括染色质重组、转录活化或抑制、细胞周期、细胞分化及细胞凋亡等一系列生物学效应的酶，特别是与细胞活化后的基因转录表达调控有关。 HDAC6是一种比较独特的组蛋白去乙酰化酶，含有两个功能上相互独立的HDAC催化结构域。HDAC6可以去乙酰化组蛋白并抑制相关基因转录。 HDAC6可以和微管(microtuble)结合，可以去乙酰化tubulin，Hsp90和cortactin等。目前发现大量的蛋白可以被乙酰化修饰，因此HDAC等乙酰化修饰酶被认为在基因转录调控、信号转导、生长发育、分化凋亡、代谢性疾病和肿瘤等多种生理病理过程中发挥重要作用。HDAC的抑制剂目前被认为是很有前景的肿瘤治疗药物。内源性HDAC6主要定位于细胞浆，与微管相结合并且是一个微管蛋白去乙酰化酶。HDAC6含有一个锌指结构域，该结构域可能和泛素化降解的调节有关。HDAC6可以和DHAC11相互作用。