磷酸化核因子活化T细胞胞浆蛋白2抗体

产品货号：

BN40826R
中文名称：

磷酸化核因子活化T细胞胞浆蛋白2抗体
英文名称：

Rabbit anti-phospho-NFATc2 (Ser326) Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40826R-100ul

100ul

¥2470.00

交叉反应：Human(predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse) 推荐应用：WB,Flow-Cyt,ELISA

产品描述

英文名称	phospho-NFATc2 (Ser326)
中文名称	磷酸化核因子活化T细胞胞浆蛋白2抗体
别名	AI607462; KIAA0611; NF ATp; NF-ATc2; NFAT 1; NFAT pre existing subunit; NFAT transcription complex, preexisting component; NFAT1; NFAT1-D; NFATc2; NFATp; Nuclear factor of activated T cells cytoplasmic 2; Nuclear factor of activated T cells cytoplasmic calcineurin dependent 2; Nuclear factor of activated T cells pre-existing component; T cell transcription factor NFAT; NF2IP_HUMAN; Nuclear factor of activated T-cells, cytoplasmic 2; NFAT pre-existing subunit; NF-ATp; T-cell transcription factor NFAT1.
产品类型	磷酸化抗体
研究领域	信号转导细胞凋亡转录调节因子激酶和磷酸酶
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1ug/test not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	102kDa
细胞定位	细胞核细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated Synthesised phosphopeptide derived from human NFATc2 around the phosphorylation site of Ser326:KT(p-S)PD
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012] Function: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway. Subunit: Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. The phosphorylated form specifically interacts with XPO1; which mediates nuclear export. NFATC proteins bind to DNA as monomers. Interacts with NFATC2IP. Subcellular Location: Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. Tissue Specificity: Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas. Post-translational modifications: In resting cells, phosphorylated by NFATC-kinase on at least 18 sites in the 99-365 region. Upon cell stimulation, all these sites except Ser-245 are dephosphorylated by calcineurin. Dephosphorylation induces a conformational change that simultaneously exposes an NLS and masks an NES, which results in nuclear localization. Simultaneously, one site among Ser-53; Ser-54 and Ser-56 is phosphorylated; which is required for full transcriptional activity. Similarity: Contains 1 RHD (Rel-like) domain SWISS: Q13469 Gene ID: 4773 Database links: Entrez Gene: 4773 Human Entrez Gene: 18019 Mouse Entrez Gene: 311658 Rat Omim: 600490 Human SwissProt: Q13469 Human SwissProt: Q60591 Mouse Unigene: 713650 Human Unigene: 744148 Human Unigene: 116802 Mouse Unigene: 33679 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.