沉默调节相关蛋白2抗体

产品货号：

BN40810R
中文名称：

沉默调节相关蛋白2抗体
英文名称：

Rabbit anti-SIRT2 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40810R-100ul

100ul

¥2360.00

交叉反应：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,IHC-P
BN40810R-200ul

200ul

¥3490.00

交叉反应：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,IHC-P

产品描述

英文名称	SIRT2
中文名称	沉默调节相关蛋白2抗体
别名	FLJ35621; FLJ37491; NAD dependent deacetylase sirtuin 2; NAD-dependent deacetylase sirtuin-2; Regulatory protein SIR2 homolog 2; Silencing information regulator 2 like; Silent information regulator 2; Silent mating type information regulation 2; Silent mating type information regulation 2 homolog; SIR 2; SIR2; SIR2 like; SIR2 like protein 2; Sir2 related protein type 2; SIR2-like protein 2; SIR2L; SIR2L2; SIRT 2; SIRT2; SIRT2_HUMAN; Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae); Sirtuin 2; Sirtuin type 2; Sirtuin2.
研究领域	细胞生物信号转导细胞周期蛋白转录调节因子表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Mouse, Rat, (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
产品应用	WB=1:500-2000 IHC-P=1:400-800 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	26kDa
细胞定位	细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human SIRT2:261-360/389
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010] Function: NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Subcellular Location: Cytoplasm, cytoskeleton. Colocalizes with microtubules. Tissue Specificity: Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network. Post-translational modifications: Phosphorylated at the G2/M transition of the cell cycle. Similarity: Belongs to the sirtuin family. Contains 1 deacetylase sirtuin-type domain. SWISS: Q8IXJ6 Gene ID: 22933 Database links: Entrez Gene: 22933 Human Omim: 604480 Human SwissProt: Q8IXJ6 Human Unigene: 466693 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.