血管紧张素转换酶2抗体

产品货号：

BN40789R
中文名称：

血管紧张素转换酶2抗体
英文名称：

Rabbit anti-ACE2 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40789R-100ul

100ul

¥2360.00

交叉反应：Human(predicted:Mouse,Rat) 推荐应用：WB,IHC-P,IHC-F,ICC,IF
BN40789R-200ul

200ul

¥3490.00

交叉反应：Human(predicted:Mouse,Rat) 推荐应用：WB,IHC-P,IHC-F,ICC,IF

产品描述

英文名称	IRS-4
中文名称	胰岛素受体底物-4抗体
别名	IRS4; 160 kDa phosphotyrosine protein; Insulin receptor substrate 4; IRS 4; PY160; IRS4_HUMAN; IRS-4; Phosphoprotein of 160 kDa; pp160.
研究领域	心血管信号转导细胞凋亡糖尿病
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, (predicted: Rat, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	134kDa
细胞定位	细胞浆细胞膜
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human IRS-4:551-650/1257
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	IRS4 (Insulin receptor substrate 4) is a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signaling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation. Function: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May acts as negative regulators of the IGFI signaling pathway by suppressing the function of IRS1 and IRS2. Subunit: Interacts with CRK and CRKL. Interaction with CRK is stronger than with CRKL. Interacts with CRK via the phosphorylated YXXM motifs. Interacts with PLC-gamma, SHC1, PTK6, PPP4C and NISCH. Interacts with SOCS6 in response to stimulatiom with either insulin or IGF1. Interacts with PIK3R1 and GRB2. Subcellular Location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Tissue Specificity: Expressed in skeletal muscle, brain, heart, kidney and liver. Post-translational modifications: Phosphorylated on tyrosine residues in response to both insulin and IGF1 signaling. Phosphorylated on Tyr-894 in response to FGF2 signaling. Phosphorylation of Tyr-894 is required for GRB2, phospholipase C-gamma and phosphatidylinositol 3-kinase interaction. Similarity: Contains 1 IRS-type PTB domain. Contains 1 PH domain. SWISS: O14654 Gene ID: 8471 Database links: Entrez Gene: 8471 Human Entrez Gene: 16370 Mouse Entrez Gene: 315350 Rat Omim: 603510 Human SwissProt: O14654 Human SwissProt: Q9Z0Y7 Mouse Unigene: 460872 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.