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BN40743R-100ul
100ul
¥2360.00
交叉反应：Mouse(predicted:Human) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA
BN40743R-200ul
200ul
¥3490.00
交叉反应：Mouse(predicted:Human) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA
产品描述
| 英文名称 | Caspase-12 |
| 中文名称 | 半胱胺酸蛋白酶蛋白-12抗体 |
| 别 名 | Caspase-12; UNQ9415; Apoptosis related cysteine protease; CASP 12; casp12; CASP12P1; Caspase 12 pseudogene 1; CASP-12; casp12; caspase 12 (gene/pseudogene); Caspase12; CASPC_HUMAN; OTTHUMP00000207026; OTTHUMP00000207028; OTTHUMP00000207031; OTTHUMP00000207032; OTTHUMP00000219058; UNQ9415. |
| 研究领域 | 细胞生物 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, (predicted: Human, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 38kDa |
| 细胞定位 | 细胞浆 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Caspase-12:21-100/341 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011] Function: Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF. Tissue Specificity: Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis. Similarity : Belongs to the peptidase C14A family. Similarity: Belongs to the peptidase C14A family. Contains 1 CARD domain. SWISS: Q6UXS9 Gene ID: 100506742 Database links: Entrez Gene: 100506742 Human SwissProt: Q6UXS9 Human Unigene: 476989 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. ASPASE-12是caspase家族成员，是存在于内质网上的促凋亡因子，内质网应激早期可通过GRP（glucose-regulated protein，GRP）的表达增多来保护细胞；CASPASE-12是内质网细胞关键介导因子，caspase-12还是caspase-1的抑制剂。 |
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