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最近搜索：细胞培养 微生物学 分子生物 生物化学
首页>>免疫学>>一抗>>抗酒石酸酸性磷酸酶5型/5型酸性磷酸酶抗体
抗酒石酸酸性磷酸酶5型/5型酸性磷酸酶抗体
  • 产品货号：
    BN40738R
  • 中文名称：
    抗酒石酸酸性磷酸酶5型/5型酸性磷酸酶抗体
  • 英文名称：
    Rabbit anti-Tartrate Resistant Acid Phosphatase Polyclonal antibody
  • 品牌：
    Biorigin

  • 货号

    产品规格

    售价

    备注

  • BN40738R-100ul

    100ul

    ¥2360.00

    交叉反应：Human(predicted:Mouse,Rat) 推荐应用：WB

  • BN40738R-200ul

    200ul

    ¥3490.00

    交叉反应：Human(predicted:Mouse,Rat) 推荐应用：WB

产品描述

英文名称Tartrate Resistant Acid Phosphatase
中文名称抗酒石酸酸性磷酸酶5型/5型酸性磷酸酶抗体
别    名Type 5 acid phosphatase; Acid phosphatase 5 tartrate resistant; ACP5; PPA5_HUMAN; T5ap; Tartrate resistant acid ATPase; Tartrate resistant acid phosphatase type 5; Tartrate resistant acid phosphatase type 5 precursor; Tartrate-resistant acid ATPase; Tartrate-resistant acid phosphatase type 5; TR AP; TR-AP; TrATPase; Type 5 acid phosphatase.  
研究领域肿瘤  细胞生物  免疫学  信号转导  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,  (predicted: Mouse, Rat, )
产品应用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量34kDa
细胞定位细胞浆 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Tartrate Resistant Acid Phosphatase :211-310/325 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
产品介绍Tartrate-resistant acid phosphatase is an iron containing glycoprotein that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. TRAP is the most basic of the acid phosphatases and is the only form not inhibited by L+-tartrate. TRAP is a relatively minor lysosomal enzyme which may be activated in certain pathologies such as Hodgkin’s disease and B- and T-cell leukemias. Receptor activator of NFκB ligand (RANKL) plays an essential role in osteoclast differentiation and activation by increasing the expression of protease osteoclast markers such as TRAP. TRAP has collagenolytic activity and plays a major role in ligament degradation.

Function:
Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.

Subunit:
Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).

Subcellular Location:
Lysosome.

DISEASE:
Defects in ACP5 are the cause of spondyloenchondrodysplasia with immune dysregulation (SPENCDI) [MIM:607944]. A disease characterized by vertebral and metaphyseal dysplasia, spasticity with cerebral calcifications, and strong predisposition to autoimmune diseases. The skeletal dysplasia is characterized by radiolucent and irregular spondylar and metaphyseal lesions that represent islands of chondroid tissue within bone. Note=ACP5 inactivating mutations result in a functional excess of phosphorylated osteopontin causing deregulation of osteopontin signaling and consequential autoimmune disease.

Similarity:
elongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

SWISS:
P13686

Gene ID:
54

Database links:

Entrez Gene: 54 Human

Entrez Gene: 11433 Mouse

Entrez Gene: 25732 Rat

Omim: 171640 Human

SwissProt: P13686 Human

SwissProt: Q05117 Mouse

SwissProt: P29288 Rat

Unigene: 1211 Human

Unigene: 46354 Mouse

Unigene: 171928 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

抗酒石酸盐酸性磷酸酶(Tartrate-Resistant Acid Phosphatase,TRAP)是破骨细胞功能的重要标志物,它的活性与破骨细胞活性呈正相关.





















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