钠离子/氢离子交换蛋白3抗体

产品货号：

BN40706R
中文名称：

钠离子/氢离子交换蛋白3抗体
英文名称：

Rabbit anti-hydrogen exchanger 3 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40706R-100ul

100ul

¥2360.00

交叉反应：Human(predicted:Mouse,Rat,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB
BN40706R-200ul

200ul

¥3490.00

交叉反应：Human(predicted:Mouse,Rat,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB

产品描述

英文名称	hydrogen exchanger 3
中文名称	钠离子/氢离子交换蛋白3抗体
别名	Na(+)/H(+) exchanger 3; NHE 3; NHE-3; NHE3; SL9A3_HUMAN; SLC9A 3; Sodium; Slc9a3; Sodium/hydrogen exchanger 3; Sodium/hydrogen exchanger, apical epithelial; Solute carrier family 9 (sodium/hydrogen exchanger), isoform 3; Solute carrier family 9 (sodium/hydrogen exchanger), member 3; Solute carrier family 9 member 3; MGC126718; MGC126720.
研究领域	肿瘤细胞生物信号转导通道蛋白细胞膜蛋白
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, (predicted: Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
产品应用	WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	93kDa
细胞定位	细胞膜
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human hydrogen exchanger 3 :451-550/834 <Cytoplasmic>
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	NHE-3 are integral membrane proteins that are expressed in most mammalian tissues, where they regulate intracellular pH and cell volume. NHEs mediate the transport of hydrogen (H+) ions out of cells in exchange for extracellular sodium (Na+) ions. While NHE-1 is ubiquitously expressed, the NHE isoforms 2-8 have distinct tissue- and cell type-dependent expression and inhibitory characteristics. NHE-3 localizes to the apical membrane of renal proximal tubules where it is responsible for most of the sodium transport and fluid reabsorption. NHE-3 translocates to internal pools where it mediates natriuresis when blood pressure increases abruptly. NHE-3 is also expressed in the stomach and functions to protect the mucosa by secreting protons that diffuse into the mucous cells. Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Subunit: Binds SLC9A3R1 and SLC9A3R2. Interacts with CHP1, CHP2 and SHANK2. Interacts with PDZD3 and interactions decrease in response to elevated calcium ion levels Subcellular Location: Membrane. In intestinal epithelial cells, localizes to the ileal brush border. Post-translational modifications: Phosphorylated by PKA, which inhibits activity. Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. SWISS: P48764 Gene ID: 6550 Database links: Entrez Gene: 6550 Human Entrez Gene: 24784 Rat Omim: 182307 Human SwissProt: P48764 Human SwissProt: P26433 Rat Unigene: 658120 Human Unigene: 9706 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.