去整合素样金属蛋白酶28抗体

产品货号：

BN40704R
中文名称：

去整合素样金属蛋白酶28抗体
英文名称：

Rabbit anti-ADAM28 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40704R-100ul

100ul

¥2360.00

交叉反应：Human 推荐应用：IHC-P
BN40704R-200ul

200ul

¥3490.00

交叉反应：Human 推荐应用：IHC-P

产品描述

英文名称	ADAM28
中文名称	去整合素样金属蛋白酶28抗体
别名	A disintegrin and metalloproteinase domain 28; ADAM28; ADAM 28; ADAM-28; MDC L; Metalloproteinase like disintegrin like and cysteine rich protein L; eMDCII; MDC-Ls; TECADAM; ADA28_HUMAN.
研究领域	肿瘤细胞生物免疫学信号转导
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human,
产品应用	IHC-P=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	87kDa
细胞定位	细胞膜分泌型蛋白
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human ADAM28:521-620/775 <Extracellular>
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	ADAM28 was first described in lymphocytes, also in Thymic Endothelial Cells (TECADAM), as well as in the epididymus. Later works describe two forms of ADAM28: ADAM28-S and ADAM28-L (short and long forms). The short form is a soluble, alternatively spliced form lacking the transmembrane and cytoplasmic domains. Message levels of the short form were found to be much lower than the long form in the tissues studied, but these may be tissue-specific differences. In humans, ADAM28 is reported in lymphocytes by some authors and to be absent from mature lymphocytes by others. The thyroid, lung, trachea, esophagus, and stomach have been shown to express human ADAM28 message. Knockout mice lacking B cells and T cells express ADAM28 message in the thyroid, lung, trachea, esophagus, and stomach. A member of the metalloproteinase family containing disintegrin-like domains (ADAMs) the functions of ADAM28 are still poorly understood. ADAM28 contains the canonical HExxHxxxxxH zinc metalloproteinase motif, and has been shown to be proteolytically active. Other ADAMs family members (ADAM10, ADAM17) have been more thoroughly studied and are known to play key roles in inflammation, growth factor maturation and release, and a wide range of other functions. The full length ADAM28 (ADAM28 Long) sequence codes for a 775 amino acid protein with a predicted mass is 87.2 kDa, and a pI of 6.50. The soluble ADAM28 (ADAM-28 Short) is a 540 amino acid sequence, with a predicted mass of 61.3 kDa, and a pI of 6.58. Other forms of ADAM28 have been reported with slightly different carboxyterminal regions. ADAM28 may play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. It may be involved in sperm maturation. There are 2 isoforms of ADAM28: one short secreted and one long membrane bound. Subcellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Tissue Specificity: Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed preferentially in spleen. Similarity: Contains 1 disintegrin domain. Contains 1 EGF-like domain. Contains 1 peptidase M12B domain. SWISS: Q9UKQ2 Gene ID: 10863 Database links: Entrez Gene: 10863 Human Omim: 606188 Human SwissProt: Q9UKQ2 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.