运动神经元及胰腺同源蛋白1抗体

产品货号：

BN40703R
中文名称：

运动神经元及胰腺同源蛋白1抗体
英文名称：

Rabbit anti-MNX1/HLXB9 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40703R-100ul

100ul

¥2360.00

交叉反应：Human,Mouse(predicted:Rat,Chicken,Dog,Pig,Cow,Rabbit) 推荐应用：WB,ELISA
BN40703R-200ul

200ul

¥3490.00

交叉反应：Human,Mouse(predicted:Rat,Chicken,Dog,Pig,Cow,Rabbit) 推荐应用：WB,ELISA

产品描述

英文名称	MNX1/HLXB9
中文名称	运动神经元及胰腺同源蛋白1抗体
别名	HB9/HLXB9; HB 9; HB9; HLXB 9; HLXB9; Homeo box HB9; Homeobox HB9; Homeobox protein HB9; HOXHB9; MNX1; MNX1_HUMAN; Motor neuron and pancreas homeobox protein 1; Sacral agenesis autosomal dominant (Currarino triad); SCRA 1; SCRA1; SCRA1; HOXHB9.
研究领域	肿瘤细胞生物发育生物学神经生物学表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, (predicted: Rat, Chicken, Dog, Pig, Cow, Rabbit, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	41kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human MNX1/HLXB9 :201-300/401
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	The HB9 homeobox transcription factor regulates gene expression during embryonic development and also in specific adult tissues. HB9 gene mutations are implicated in Curriano syndrome, which is characterized by a triad consisting of a presacral tumor, sacral agenesis and anorectal malformation. In human bone marrow cells, HB9 expression directly correlates with CD34 expression. Furthermore, HB9 expression increases in CD34+ cells that are treated with IL-3 and granulocyte macrophage-colony-stimulating factor. Early in murine development, HB9 is expressed in pancreatic buds (dorsal and ventral) with subsequent expression in differentiating beta cells in the islets of Langerhans. The dorsal lobe of the pancreas fails to form in HB9(-) mice; the resultant pancreas has smaller islets of Langerhans and less beta cells than normal pancreas. The HB9 gene is expressed in the human adult pancreas. In the developing vertebrate embryo, the HB9 gene plays an essential role in motor neuron differentiation. The motor columns of HB9(-) mice are disorganized, lacking phrenic and abducens nerves and exhibiting intercostal nerve defects. Function: Putative transcription factor involved in pancreas development and function. Subcellular Location: Nucleus. Tissue Specificity: Expressed in lymphoid and pancreatic tissues. DISEASE: Defects in MNX1 are a cause of Currarino syndrome (CURRAS) [MIM:176450]. The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait. Similarity: Contains 1 homeobox DNA-binding domain. SWISS: P50219 Gene ID: 3110 Database links: Entrez Gene: 3110 Human Entrez Gene: 15285 Mouse Omim: 142994 Human SwissProt: P50219 Human SwissProt: Q9QZW9 Mouse Unigene: 37035 Human Unigene: 103760 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.