整合素alpha E2 抗体

产品货号：

BN40677R
中文名称：

整合素alpha E2 抗体
英文名称：

Rabbit anti-Integrin alpha E Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40677R-100ul

100ul

¥2360.00

交叉反应：Human,Mouse(predicted:Rat,Dog,Rabbit) 推荐应用：WB,IHC-F,IF,Flow-Cyt,ELISA
BN40677R-200ul

200ul

¥3490.00

交叉反应：Human,Mouse(predicted:Rat,Dog,Rabbit) 推荐应用：WB,IHC-F,IF,Flow-Cyt,ELISA

产品描述

英文名称	Integrin alpha E
中文名称	整合素alpha E2 抗体
别名	Itgae; A530055J10; alpha-E1; alpha-M290; aM290; CD103; MGC183601; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide. ITAE_HUMAN; Integrin alpha-E; HML-1 antigen; Integrin alpha-IEL; Mucosal lymphocyte 1 antigen; Integrin alpha-E heavy chain; integrin alpha-E precursor.
研究领域	细胞生物免疫学信号转导干细胞细胞粘附分子
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, (predicted: Rat, Dog, Rabbit, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-F=1:100-500 Flow-Cyt=1ug/test IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	110/128kDa
细胞定位	细胞膜
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Integrin alpha-E heavy chain:1101-1179/1179 <Cytoplasmic>
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	CD103/Integrin alpha E is a new member of the integrin series of adhesion molecules containing the beta7 subunit. This antigen defines a developmentally important subset of T cells, namely mucosal T cells including all IEL (intraepithelial lymphocytes) and ~20% of lamina propria T cells. Expression of CD103 is more restricted outside these mucosal organs, appearing at lower levels on T cell subsets of the lymph node, dendritic epidermis and periphery. In non-epithelial CD103+ T cells there is a bias toward expression on CD8+ cells. Integrin alpha E is a heterodimer comprising a 150kDa alpha chain and a 120kDa beta chain. Integrin alpha E is expressed by approximately 1% of peripheral blood lymphocytes, activated T lymphocytes and by hairy cell leukaemia cells. The antigen is also expressed by intraepithelial lymphocytes. Function: Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7. Subcellular Location: Membrane; Single-pass type I membrane protein. Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells. Tissue Specificity: Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located between mucosal epithelial cells. Similarity: Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. Contains 1 VWFA domain. SWISS: P38570 Gene ID: 3682 Database links: Entrez Gene: 3682 Human Omim: 604682 Human SwissProt: P38570 Human Unigene: 513867 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.