金属蛋白酶组织抑制因子-2抗体

产品货号：

BN40664R
中文名称：

金属蛋白酶组织抑制因子-2抗体
英文名称：

Rabbit anti-TIMP-2 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40664R-100ul

100ul

¥2360.00

交叉反应：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF
BN40664R-200ul

200ul

¥3490.00

交叉反应：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF

产品描述

英文名称	TIMP-2
中文名称	金属蛋白酶组织抑制因子-2抗体
别名	Metalloproteinase inhibitor 2 precursor; Tissue inhibitor of metalloproteinases 2; Collagenase inhibitor; CSC 21K; CSC21K; TIMP2; TIMP 2; TIMP 2; TIMP metallopeptidase inhibitor 2; TIMP2_HUMAN; Metalloproteinase inhibitor 2; CSC-21K; TIMP-2.
研究领域	肿瘤心血管细胞生物神经生物学信号转导细胞凋亡生长因子和激素合成与降解
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Mouse, Rat, (predicted: Human, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, )
产品应用	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	24kDa
细胞定位	分泌型蛋白
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human TIMP-2 :31-130/220
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]. Function: : Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. Subunit: : Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. Subcellular Location: Secreted. Post-translational modifications: The activity of TIMP2 is dependent on the presence of disulfide bonds. Similarity: Belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain. SWISS: P16035 Gene ID: 7077 Database links: Entrez Gene: 282093 Cow Entrez Gene: 100135629 Guinea pig Entrez Gene: 7077 Human Entrez Gene: 21858 Mouse Entrez Gene: 100008689 Rabbit Entrez Gene: 29543 Rat Omim: 188825 Human SwissProt: P16368 Cow SwissProt: Q9WUC6 Guinea pig SwissProt: P16035 Human SwissProt: P25785 Mouse SwissProt: Q9TRZ7 Rabbit SwissProt: P30121 Rat Unigene: 633514 Human Unigene: 206505 Mouse Unigene: 10161 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 合成与降解（Synthesis and Degradation） TIMP-2与TIMP-1一样是基质金属蛋白酶的抑制酶，其功能与MMP相反，能抑制肿瘤细胞的浸润和转移，主要用于各种恶性肿瘤如乳腺癌等的研究。TIMP-2又称为CSC-21K，是一种21-24kDa的糖蛋白，在多种组织细胞中表达，它可以和MMPs家族成员以共价键方式形成复合物，从而发挥其抑制作用。在正常生理条件下，MMPs和TIMPs之间的平衡状态是维持细胞外基质正常状态所必需的，一旦它们之间的比例失调，就会造成一系列的病理状态。