线粒体脱偶连蛋白2抗体

产品货号：

BN40644R
中文名称：

线粒体脱偶连蛋白2抗体
英文名称：

Rabbit anti-UCP-2 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40644R-100ul

100ul

¥2360.00

交叉反应：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,IHC-P,IHC-F,IF
BN40644R-200ul

200ul

¥3490.00

交叉反应：Human,Mouse(predicted:Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,IHC-P,IHC-F,IF

产品描述

英文名称	UCP-2
中文名称	线粒体脱偶连蛋白2抗体
别名	Uncoupling Protein-2; UCP2; UCP 2; BMIQ4; Mitochondrial uncoupling protein 2; SLC25A8; UCPH; Uncoupling protein 2; Uncoupling protein 2 mitochondrial proton carrier; Solute carrier family 25 member 8; UCP2_HUMAN.
研究领域	细胞生物免疫学染色质和核信号糖尿病
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
产品应用	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	34kDa
细胞定位	细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human UCP-2:121-220/309
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. UCP2 gene is expressed in many tissues, with the greatest expression in skeletal muscle. UCP2 is thought to play a role in non shivering thermogenesis, obesity and diabetes. Function: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. Subunit: Acts as a dimer forming a proton channel (By similarity). Subcellular Location: Mitochondrion inner membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle. Similarity: Belongs to the mitochondrial carrier family. Contains 3 Solcar repeats. SWISS: P55851 Gene ID: 7351 Database links: Entrez Gene: 7351 Human Entrez Gene: 54315 Rat Omim: 601693 Human SwissProt: P55851 Human SwissProt: P56500 Rat Unigene: 80658 Human Unigene: 13333 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. UCP-2又称解耦联蛋白 2 (UCP2 )是 1997年发现的一种新的解偶联蛋白 ,它是线粒体内膜载体家族的一员。与其类似物UCP1相比 ,UCP2在棕色脂肪组织中含量较低 ,但在体内分布广泛。解耦联蛋白(UCP)具有使线粒体呼吸链解耦联作用,解耦联所释放的能量以热能的形式散发。在对UCP与产热关系的研究中,发现UCP2具有调节机体能量代谢的功能,并且可能是肥胖与2型糖尿病相关联的一个重要基因。