胰岛素受体底物-2抗体

产品货号：

BN40643R
中文名称：

胰岛素受体底物-2抗体
英文名称：

Rabbit anti-IRS-2 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40643R-100ul

100ul

¥2360.00

交叉反应：Human,Rat(predicted:Mouse,Horse) 推荐应用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA
BN40643R-200ul

200ul

¥3490.00

交叉反应：Human,Rat(predicted:Mouse,Horse) 推荐应用：IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

产品描述

英文名称	IRS-2
中文名称	胰岛素受体底物-2抗体
别名	Insulin Receptor Substrate 2; IRS 2; IRS-2; IRS2; IRS2_HUMAN.
研究领域	细胞生物神经生物学信号转导细胞凋亡细胞膜受体糖尿病
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Rat, (predicted: Mouse, Horse, )
产品应用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	146kDa
细胞定位	细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human IRS-2:461-560/1338
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008] Function: May mediate the control of various cellular processes by insulin. Subunit: Interacts with PHIP. Subcellular Location: Cytoplasm, cytosol. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 1 IRS-type PTB domain. Contains 1 PH domain. SWISS: Q9Y4H2 Gene ID: 8660 Database links: Entrez Gene: 8660 Human Entrez Gene: 384783 Mouse Entrez Gene: 29376 Rat Omim: 600797 Human SwissProt: Q9Y4H2 Human SwissProt: P81122 Mouse Unigene: 442344 Human Unigene: 407207 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. IRS-2是肝胰岛素信号转导核心介子，IRS-2基因的缺失或IRS-2信号网络上一些关键信号分子的异常改变，都将导致肝胰岛素信号转导能力减弱，出现肝胰岛素抵抗.