TIP60相关蛋白54α抗体

产品货号：

BN40578R
中文名称：

TIP60相关蛋白54α抗体
英文名称：

Rabbit anti-TIP49A Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40578R-100ul

100ul

¥2360.00

交叉反应：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA
BN40578R-200ul

200ul

¥3490.00

交叉反应：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

产品描述

英文名称	RUVBL1
中文名称	RUVBL1抗体
别名	49 kDa TATA box binding protein interacting protein; 49 kDa TATA box-binding protein-interacting protein; 49 kDa TBP interacting protein; 49 kDa TBP-interacting protein; 54 kDa erythrocyte cytosolic protein; ECP-54; ECP54; ERYTHROCYTE CYTOSOLIC PROTEIN, 54-KD; INO80 complex subunit H; NMP 238; Nuclear matrix protein 238; Pontin 52; PONTIN; RuvB like 1; RuvB-like 1; RUVB1_HUMAN; RVB1; TAP54 alpha; TAP54-alpha; TIP49; TIP49A; TIP60 associated protein 54 alpha; TIP60-associated protein 54-alpha.
研究领域	肿瘤细胞生物信号转导细胞凋亡转录调节因子
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Mouse, (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	50kDa
细胞定位	细胞核细胞浆细胞膜
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human RUVBL1:101-200/456
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This gene encodes a protein that has both DNA-dependent ATPase and DNA helicase activities and belongs to the ATPases associated with diverse cellular activities (AAA+) protein family. The encoded protein associates with several multisubunit transcriptional complexes and with protein complexes involved in both ATP-dependent remodeling and histone modification. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] Function: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May be able to bind plasminogen at cell surface and enhance plasminogen activation. Essential for cell proliferation. Subcellular Location: Nucleus matrix. Nucleus > nucleoplasm. Cytoplasm. Membrane. Cytoplasm > cytoskeleton > centrosome. Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol, although it is also present in the cytoplasm and associated with the cell membranes. In prophase and prometaphase it is located at the centrosome and the branching microtubule spindles. After mitotic nuclear membrane disintigration it accumulates at the centrosome and sites of tubulin polymerization. As cells pass through metaphase and into telophase it is located close to the centrosome at the early phase of tubulin polymerization. In anaphase it accumulates at the zone of tubule interdigitation. In telophase it is found at polar tubule overlap, and it reappears at the site of chromosomal decondensation in the daughter cells. Tissue Specificity: Ubiquitously expressed with high expression in heart, skeletal muscle and testis. Similarity: Belongs to the ruvB family. SWISS: Q9Y265 Gene ID: 8607 Database links: Entrez Gene: 8607 Human Entrez Gene: 56505 Mouse Entrez Gene: 65137 Rat Omim: 603449 Human SwissProt: Q9Y265 Human SwissProt: P60122 Mouse SwissProt: P60123 Rat Unigene: 272822 Human Unigene: 42195 Mouse Unigene: 86410 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.