HER2受体转换蛋白抗体

产品货号：

BN40511R
中文名称：

HER2受体转换蛋白抗体
英文名称：

Rabbit anti-TOB Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40511R-100ul

100ul

¥2360.00

交叉反应：Rat(predicted:Human,Mouse,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA
BN40511R-200ul

200ul

¥3490.00

交叉反应：Rat(predicted:Human,Mouse,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA

产品描述

英文名称	TOB
中文名称	HER2受体转换蛋白抗体
别名	APRO 6; APRO6; MGC104792; MGC34446; PIG 49; PIG49; Proliferation inducing gene 49; Protein Tob1; RP23 244C22.1; TOB 1; Tob 1 protein; TOB; TOB1; Tob1 protein; Transducer of ERBB 2 1; Transducer of erbB 2; Transducer of ERBB2 1; Transducer of erbB2; Trob; TOB1_HUMAN; TROB 1; TROB1.
研究领域	肿瘤细胞生物免疫学染色质和核信号信号转导转录调节因子
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Rat, (predicted: Human, Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
产品应用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	38kDa
细胞定位	细胞核细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human TOB:131-230/345
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] Function: The Tob/Btg family of proteins consists of a large number of members. These proteins have a common domain in their amino terminal end and may have anti-proliferative activity in various cell types. The Tob protein was identified in a search for molecules that interact with the receptor tyrosine kinase ErbB2. Active ErbB2 has a negative effect on the anti-proliferative activity of Tob. However, Tob is phosphorylated on serine and threonine residues but not on tyrosine, suggesting that active ErbB2 activates a Ser/Thr kinase that phosphorylates Tob. Unphosphorylated Tob suppresses expression of cyclin D1. It was shown that active p90Rsk1 kinase (known to be activated by protein-tyrosine kinase receptor) phosphorylates Tob on serine and threonine residues in vitro. In addition, Erk1/Erk2 MAP kinases phosphorylate Tob in vivo and in vitro, resulting in suppression of the anti-proliferative activity of Tob. Homozygous Tob knockout mice develop greater bone mass resulting from increased numbers of osteoblasts. Furthermore, it has been shown in osteoblasts, that upon BMP2 (bone morphogenetic protein) activation, Tob associates with receptor regulated Smads (Smad 1, 5, and 8). Thus, osteoblast proliferation and differentiation is negatively regulated by Tob protein through the Smad proteins. Subunit: Interacts with ERBB2. Interacts with CNOT7 and CNOT8. Tissue Specificity: Ubiquitous. Post-translational modifications: Phosphorylated on Ser and Thr residues. Similarity: Belongs to the BTG family. SWISS: P50616 Gene ID: 10140 Database links: Entrez Gene: 10140 Human Entrez Gene: 22057 Mouse Entrez Gene: 170842 Rat Omim: 605523 Human SwissProt: P50616 Human SwissProt: Q61471 Mouse SwissProt: Q8R5K6 Rat Unigene: 531550 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.