T细胞白血病淋巴瘤蛋白3抗体

产品货号：

BN40495R
中文名称：

T细胞白血病淋巴瘤蛋白3抗体
英文名称：

Rabbit anti-TCL3/HOX11 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40495R-100ul

100ul

¥2360.00

交叉反应：Human,Mouse(predicted:Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep) 推荐应用：WB,ELISA
BN40495R-200ul

200ul

¥3490.00

交叉反应：Human,Mouse(predicted:Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Sheep) 推荐应用：WB,ELISA

产品描述

英文名称	TCL3/HOX11
中文名称	T细胞白血病淋巴瘤蛋白3抗体
别名	Homeo box 11 (T cell leukemia 3 associated breakpoint homologous to Drosophila Notch); Homeo box 11 (T cell lymphoma 3 associated breakpoint); Homeobox 11; Homeobox protein Hox 11; Homeobox protein Hox-11; Homeobox TLX-1; Hox-11; Hox11; MGC163402; OTTHUMP00000020816; Proto oncogene TCL 3; Proto-oncogene TCL-3; RGD1563655; T cell leukemia homeobox protein 1; T cell leukemia lymphoma protein 3; T-all, included; T-cell acute lymphocytic leukemia, included; T-cell leukemia 3 gene; T-cell leukemia homeobox protein 1; T-cell leukemia, homeobox 1; T-cell leukemia/lymphoma protein 3; TCL 3 proto oncogene; TCL3; Tlx-1; TLX1; TLX1_HUMAN.
研究领域	肿瘤细胞生物发育生物学转录调节因子表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	34kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human TCL3/HOX11:121-220/330
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. The Hox11 gene, termed an orphan homeobox gene, as it is located outside of the four mammalian Hox clusters, is a DNA-binding nuclear transcription factor. The human Hox11 gene maps to chromosome 10q24 and has been implicated in the chromosomal translocation t(7;10)(q24;q11) that occurs in T-cell acute lymphoblastic leukemia (T-ALL). The t(7:10) translocation occurs between the Hox11 gene and the T-cell receptor (TCR) delta-chain gene and is a result of aberrant physiological recombinational events at the early stages of T-cell development. The Hox11 gene is normally expressed in the splanchnic anlage arising from the splanchnic mesoderm. Homozygous Hox11-deficient mice have no spleen, while all other splanchnic derivatives develop normally. Spleen development starts and proceeds normally in Hox11-deficient mice to a specific stage of embryogenesis, when the spleen anlage becomes fully absorbed. Function: Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'. Subcellular Location: Nucleus. DISEASE: Note=A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD. Similarity: Contains 1 homeobox DNA-binding domain. SWISS: P31314 Gene ID: 3195 Database links: Entrez Gene: 3195 Human Entrez Gene: 21908 Mouse Entrez Gene: 499361 Rat Omim: 186770 Human SwissProt: P31314 Human SwissProt: P43345 Mouse SwissProt: D4A270 Rat Unigene: 89583 Human Unigene: 391203 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.