鸟嘌呤核苷酸结合蛋白3样蛋白抗体

产品货号：

BN40424R
中文名称：

鸟嘌呤核苷酸结合蛋白3样蛋白抗体
英文名称：

Rabbit anti-GNL3L Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40424R-100ul

100ul

¥2360.00

交叉反应：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA
BN40424R-200ul

200ul

¥3490.00

交叉反应：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：IHC-P,IHC-F,ICC,IF,ELISA

产品描述

英文名称	GNL3L
中文名称	鸟嘌呤核苷酸结合蛋白3样蛋白抗体
别名	GNL3L_HUMAN; FLJ10613; Guanine nucleotide binding protein-like 3 (nucleolar)-like; novel GTPase; OTTHUMP00000023374.
研究领域	细胞生物免疫学染色质和核信号 G蛋白偶联受体 G蛋白信号
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Mouse, Rat, (predicted: Human, Dog, Pig, Cow, Horse, Rabbit, )
产品应用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	66kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human GNL3L:210-310/582
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	GTPases from the MMR1/HSR1 GTP-binding protein subfamily are circularly rearranged G-motifs that play a critical role in maintaining normal cell growth. Deletion of these genes results in severe growth defects with a marked reduction in mature rRNA species and a concomitant accumulation of the 35S pre-rRNA transcript. Deletion also causes the ribosomal protein Rpl25a to fail exportation from the nucleolus. Deletion of any of the G-domain motifs will result in a null phenotype and nuclear/nucleolar localization that lacks the nucleolar export of preribosomes and is accompanied by a distortion of the nucleolar structure. GNL3L (guanine nucleotide binding protein-like 3 (nucleolar)-like) is a 582 amino acid nuclear protein that belongs to the MMR1/HSR1 GTP-binding protein family. Containing one G (guanine nucleotide-binding) domain, GNL3L is required for normal processing of ribosomal pre-rRNA and for cell proliferation. Function: Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. Subunit: Interacts with MDM2; this interaction, which occurs in the nucleoplasm, stabilizes MDM2. Indirectly interacts with TP53, via MDM2-binding. Interacts with TERF1; this interaction probably occurs in the nucleoplasm and is increased during mitosis, when the nucleolus is disassembled. This binding may promote TERF1 homodimerization. Interacts with TERT. Subcellular Location: Nucleus, nucleolus. Similarity: Belongs to the MMR1/HSR1 GTP-binding protein family. Contains 1 G (guanine nucleotide-binding) domain. SWISS: Q9NVN8 Gene ID: 54552 Database links: Entrez Gene: 54552 Human SwissProt: Q9NVN8 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.