氧化还原酶GlyR1/核蛋白60抗体

产品货号：

BN40422R
中文名称：

氧化还原酶GlyR1/核蛋白60抗体
英文名称：

Rabbit anti-GLYR1 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40422R-100ul

100ul

¥2360.00

交叉反应：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Monkey) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA
BN40422R-200ul

200ul

¥3490.00

交叉反应：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Monkey) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

产品描述

英文名称	GLYR1
中文名称	氧化还原酶GlyR1/核蛋白60抗体
别名	3 hydroxyisobutyrate dehydrogenase like protein; 3-hydroxyisobutyrate dehydrogenase-like protein; BM045; Cytokine like nuclear factor n pac; Cytokine-like nuclear factor N-PAC; Glyoxylate reductase 1 homolog; GLYR1; GLYR1_HUMAN; HIBDL; N-PAC; NP60; Nuclear protein 60 kDa; Nuclear protein NP60; Nuclear protein of 60 kDa; Putative oxidoreductase GLYR1.
研究领域	细胞生物信号转导激酶和磷酸酶表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Mouse, (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Monkey, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	61kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human GLYR1/NP60:21-120/553
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	NP60 is a 553 amino acid nuclear protein that regulates the phosphorylation and activation of p38 alpha in response to stress. There are five isoforms of NP60 that are produced as a result of alternative splicing events. Function: May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3). Subunit: Interacts with MAPK14. Subcellular Location: Nucleus. Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family. NP60 subfamily. Contains 1 A.T hook DNA-binding domain. Contains 1 PWWP domain. SWISS: Q49A26 Gene ID: 84656 Database links: Entrez Gene: 84656 Human Entrez Gene: 74022 Mouse Entrez Gene: 360477 Rat Omim: 610660 Human SwissProt: Q49A26 Human SwissProt: Q922P9 Mouse SwissProt: Q5RKH0 Rat Unigene: 387255 Human Unigene: 21652 Mouse Unigene: 2639 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.