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BN40421R-100ul
100ul
¥2360.00
交叉反应：Human(predicted:Mouse,Rat,Chicken,Cow,Rabbit,Monkey) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA
BN40421R-200ul
200ul
¥3490.00
交叉反应：Human(predicted:Mouse,Rat,Chicken,Cow,Rabbit,Monkey) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA
产品描述
| 英文名称 | GPX7 |
| 中文名称 | 谷胱甘肽过氧化酶7抗体 |
| 别 名 | CL683; FLJ14777; Glutathione peroxidase 7; GPx-7; GPX6; GPX7; GPX7_HUMAN; GSHPx-7; NPGPx. |
| 研究领域 | 细胞生物 信号转导 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, (predicted: Mouse, Rat, Chicken, Cow, Rabbit, Monkey, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 19kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GPX7/Glutathione Peroxidase 7:11-110/187 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | Glutathione peroxidase (GPx) enzymes are generally selenium-containing tetrameric glycoproteins that help prevent lipid peroxidation of cell membranes. GPx enzymes reduce lipid hydroperoxides to alcohols and reduce free hydrogen peroxide to water. GPx members are among the few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by the nonsense (stop) codon TGA. There are eight GPx homologs (GPx-1–8). GPx-7 (glutathione peroxidase 7), also known as GPX6, CL683 or NPGPx, is a 187 amino acid secreted protein belonging to the glutathione peroxidase family. GPx-7 catalyzes the reaction of glutathione into glutathione disulfide and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Function: It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks. Subcellular Location: Secreted. Tissue Specificity: Expressed in esophageal epithelial cells; expression is up-regulated after exposure to acidic bile acids. DISEASE: Defects in GPX7 are a cause of Barrett esophagus (BE) [MIM:614266]. A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Note=The pathologic mechanisms leading to Barrett esophagus involve GPX7 dysfunction that results in higher levels of hydrogen peroxide and ROS-induced oxidative stress and DNA damage in esophageal cells. Similarity: Belongs to the glutathione peroxidase family. SWISS: Q96SL4 Gene ID: 2882 Database links: Entrez Gene: 2882 Human Entrez Gene: 67305 Mouse SwissProt: Q96SL4 Human SwissProt: Q99LJ6 Mouse Unigene: 43728 Human Unigene: 20164 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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