Fcγ免疫球蛋白IgG结合蛋白抗体

产品货号：

BN40411R
中文名称：

Fcγ免疫球蛋白IgG结合蛋白抗体
英文名称：

Rabbit anti-FCGBP Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40411R-100ul

100ul

¥2360.00

交叉反应：Human,Mouse,Rat(predicted:Dog,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN40411R-200ul

200ul

¥3490.00

交叉反应：Human,Mouse,Rat(predicted:Dog,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

产品描述

英文名称	FCGBP
中文名称	Fcγ免疫球蛋白IgG结合蛋白抗体
别名	Fc fragment of IgG binding protein; FC(GAMMA)BP; Fcgamma-binding protein antigen; FcgammaBP; FCGBP; FCGBP_HUMAN; Human Fc gamma BP; IgGFc-binding protein.
研究领域	细胞生物免疫学细胞膜受体
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, (predicted: Dog, Rabbit, )
产品应用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	569kDa
细胞定位	分泌型蛋白
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human FCGBP:431-530/5405
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	Fc (Ig constant fragment) receptors ensure protection of the host against foreign antigens, such as microorganisms and pathogens, by removing Ig-coated antigen complexes from circulation. Fc receptors are present on lymphoid and myeloid derivatives, where they mediate endocytosis of Ig-antigen complexes, antibody production in B cells through T cell antigen presentation, cytotoxicity and the release of cytokines and reactive oxygen species. The Fc γ-binding protein (FCGBP) interacts with the Fc portion of IgG and MUC2 to mediate the maintenance of the mucosal structure. FCGBP is a 5,405 amino acid protein that contains twelve TIL (trypsin inhibitory-like) domains and thirteen VWFD domains. It is predominantly expressed in placenta and colon epithelium as well as in thyroid and serum. Patients with various autoimmune diseases seemingly have higher levels of FCGBP protein present in their serum. Function: May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa. Subunit: Interacts with the Fc portion of IgG and with MUC2. Subcellular Location: Secreted. Tissue Specificity: Mainly expressed in placenta and colon epithelium. Expressed in thyroid, and down-regulated in thyroid carcinomas. Present in serum, with higher levels in patients with various autoimmune diseases (at protein level). Similarity: Contains 12 TIL (trypsin inhibitory-like) domains. Contains 13 VWFD domains. SWISS: Q9Y6R7 Gene ID: 8857 Database links: Entrez Gene: 8857 Human SwissProt: Q9Y6R7 Human Unigene: 111732 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.