双特异性蛋白磷酸酶10抗体

产品货号：

BN40403R
中文名称：

双特异性蛋白磷酸酶10抗体
英文名称：

Rabbit anti-DUSP10 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40403R-100ul

100ul

¥2360.00

交叉反应：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA
BN40403R-200ul

200ul

¥3490.00

交叉反应：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

产品描述

英文名称	DUSP10
中文名称	双特异性蛋白磷酸酶10抗体
别名	MKP5; MKP 5; MKP-5; Dual specificity phosphatase 10; Dual specificity phosphatase MKP 5; Dual specificity phosphatase MKP5; Dual specificity protein phosphatase 10; DUS10_HUMAN; DUSP 10; DUSP10; DUSP10 protein; MAP kinase phosphatase 5; Mitogen activated protein kinase phosphatase 5; Mitogen-activated protein kinase phosphatase 5; Serine/threonine specific protein phosphatase.
研究领域	细胞生物信号转导细胞凋亡激酶和磷酸酶
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	53kDa
细胞定位	细胞核细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human DUSP10/MKP5:161-260/482
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. MKP-5 preferentially binds to p38, but also to SAPK/JNK. It is ubiquitously expressed and localizes to both the cytoplasm and the nucleus. MKP-5 has been implicated in cell proliferation and apoptosis, tumor invasion and immune responses. Function: Involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. Subunit: Monomer. Interacts with MAPK14. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Detected in brain. Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 rhodanese domain. Contains 1 tyrosine-protein phosphatase domain. SWISS: Q9Y6W6 Gene ID: 11221 Database links: Entrez Gene: 11221 Human Entrez Gene: 63953 Mouse Entrez Gene: 63995 Rat Omim: 608867 Human SwissProt: Q9Y6W6 Human SwissProt: Q9ESS0 Mouse Unigene: 497822 Human Unigene: 404024 Mouse Unigene: 163239 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.