指甲髌骨综合征相关蛋白NPS1抗体

产品货号：

BN40328R
中文名称：

指甲髌骨综合征相关蛋白NPS1抗体
英文名称：

Rabbit anti-LMX1b Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40328R-100ul

100ul

¥2360.00

交叉反应：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA
BN40328R-200ul

200ul

¥3490.00

交叉反应：Mouse,Rat(predicted:Human,Dog,Pig,Cow,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA

产品描述

英文名称	LMX1b
中文名称	指甲髌骨综合征相关蛋白NPS1抗体
别名	LIM homeo box transcription factor 1 beta; LIM homeobox transcription factor 1 beta; LIM homeobox transcription factor 1-beta; LIM-homeobox protein 1.2; LIM/homeobox protein 1.2; LIM/homeobox protein LMX1B; LMX 1.2; LMX-1.2; LMX1.2; LMX1B; LMX1B_HUMAN; NPS 1; NPS1.
研究领域	细胞生物发育生物学神经生物学表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Mouse, Rat, (predicted: Human, Dog, Pig, Cow, Sheep, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	42kDa
细胞定位	细胞核
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human LMX1b/NPS1:111-210/379
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] Function: Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels. Subcellular Location: Nucleus. Tissue Specificity: Expressed in most tissues. Highest levels in testis, thyroid, duodenum, skeletal muscle, and pancreatic islets. DISEASE: Defects in LMX1B are the cause of nail-patella syndrome (NPS) [MIM:161200]; also known as onychoosteodysplasia. NPS is a disease that cause abnormal skeletal patterning and renal dysplasia. Similarity: Contains 1 homeobox DNA-binding domain. Contains 2 LIM zinc-binding domains. SWISS: O60663 Gene ID: 4010 Database links: Entrez Gene: 4010 Human Entrez Gene: 16917 Mouse Entrez Gene: 114501 Rat GenBank: U77457.1 Human Omim: 602575 Human SwissProt: O60663 Human SwissProt: O88609 Mouse Unigene: 129133 Human Unigene: 39825 Mouse Unigene: 92364 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.