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产品规格
售价
备注
BN40321R-100ul
100ul
¥2360.00
交叉反应：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Rabbit) 推荐应用：WB,ELISA
BN40321R-200ul
200ul
¥3490.00
交叉反应：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Rabbit) 推荐应用：WB,ELISA
产品描述
| 英文名称 | TMEM59 |
| 中文名称 | 跨膜蛋白59抗体 |
| 别 名 | C1orf8; HSPC001; Liver membrane-bound protein; TMEM59; TMEM59 transmembrane protein 59; TMM59_HUMAN; Transmembrane protein 59. |
| 研究领域 | 细胞生物 神经生物学 信号转导 Alzheimer's |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Rabbit, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 33kDa |
| 细胞定位 | 细胞浆 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TMEM59:141-240/323 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | TMEM59 is a 144 amino acid protein encoded by a gene mapping to human chromosome 1. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. Function: Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. Subcellular Location: Golgi apparatus membrane. Post-translational modifications: N-glycosylated. Similarity: Belongs to the TMEM59 family. SWISS: Q9BXS4 Gene ID: 9528 Database links: Entrez Gene: 9528 Human Entrez Gene: 56374 Mouse SwissProt: Q9BXS4 Human SwissProt: Q9QY73 Mouse Unigene: 726034 Human Unigene: 291192 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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