脊髓性肌萎缩症蛋白SMA抗体

产品货号：

BN40312R
中文名称：

脊髓性肌萎缩症蛋白SMA抗体
英文名称：

Rabbit anti-Gemin 2 Polyclonal antibody
品牌：

Biorigin

货号

产品规格

售价

备注
BN40312R-100ul

100ul

¥2360.00

交叉反应：Human,Rat(predicted:Mouse,Pig,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA
BN40312R-200ul

200ul

¥3490.00

交叉反应：Human,Rat(predicted:Mouse,Pig,Horse,Rabbit) 推荐应用：WB,IHC-P,IHC-F,IF,ELISA

产品描述

英文名称	Gemin 2
中文名称	脊髓性肌萎缩症蛋白SMA抗体
别名	SMA; Gemin2; Component of gems 2; Gem (nuclear organelle) associated protein 2; Gem associated protein 2; GEMI2_HUMAN; Gemin-2; gemin2; SIP 1; SIP-1; SIP1; SIP1 delta; SIP1-delta ; SMN interacting protein 1; SMN interacting protein 1 delta; SMN-interacting protein 1; Survival interacting protein 1; Survival of motor neuron protein interacting protein 1; Survival of motor neuron protein-interacting protein 1.
研究领域	细胞生物神经生物学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Rat, (predicted: Mouse, Pig, Horse, Rabbit, )
产品应用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	32kDa
细胞定位	细胞核细胞浆
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Gemin 2:101-200/280
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
产品介绍	This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011]. Function: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. Subunit: Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Interacts directly with GEMIN5. Subcellular Location: Nucleus, gem. Cytoplasm. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm. Similarity: Belongs to the gemin-2 family. SWISS: O14893 Gene ID: 8487 Database links: Entrez Gene: 8487 Human Entrez Gene: 66603 Mouse Entrez Gene: 84404 Rat Omim: 602595 Human SwissProt: O14893 Human SwissProt: Q9CQQ4 Mouse SwissProt: Q9QZP1 Rat Unigene: 652307 Human Unigene: 35353 Mouse Unigene: 34143 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.