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产品规格
售价
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BN40264R-100ul
100ul
¥2360.00
交叉反应：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA
BN40264R-200ul
200ul
¥3490.00
交叉反应：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推荐应用：WB,IHC-P,IHC-F,ICC,IF,ELISA
产品描述
| 英文名称 | SOCS6 |
| 中文名称 | 细胞因子信号传导抑制蛋白6抗体 |
| 别 名 | CIS-4; CIS4; Cish4; Cytokine inducible SH2 protein 4; Cytokine-inducible SH2 protein 4; HSPC060; SOCS-4; SOCS-6; SOCS4; Socs6; SOCS6_HUMAN; SSI4; STAI4; STAT induced STAT inhibitor 4; STAT4; STATI4; Suppressor of cytokine signaling 4; Suppressor of cytokine signaling 6. |
| 研究领域 | 细胞生物 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 59kDa |
| 细胞定位 | 细胞浆 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SOCS6:21-120/535 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]. Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. Subunit: Interacts with RBCK1. Interacts with phosphorylated IRS4. Interacts with PIM3. Interacts with KIT (phosphorylated). Similarity: Contains 1 SH2 domain. Contains 1 SOCS box domain. SWISS: O14544 Gene ID: 9306 Database links: Entrez Gene: 9306 Human Entrez Gene: 54607 Mouse Omim: 605118 Human SwissProt: O14544 Human SwissProt: Q9JLY0 Mouse Unigene: 44439 Human Unigene: 476577 Mouse Unigene: 91920 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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